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Flow Gel
Tumor cells go against the flow (MIT)
Cancer's uncontrolled spread throughout the body is what makes the disease so
deadly. To shed some light on the spreading process, mechanical engineers at
MIT have developed a microfluidic model to better understand how cancer cells
break loose from their original tumor, make their way into the body's vascular
system and travel around the body.
Using that microfluidic device, Professor Roger Kamm and mechanical
engineering graduate student William Polacheck, in collaboration with Joseph
Charest from the Charles Stark Draper Laboratory, have discovered that the
direction in which fluid flows through bodily tissue determines how likely
cancer cells are to spread, or metastasize. Armed with that information, they
say, it may be possible to limit the spread of cancer.
Almost as important as their discovery — described in a recent issue of
_Proceedings of the National Academy of Sciences_ — is the 3-D microfluidic
system they invented that led to it. Whereas previous insights were based
solely on visualizing individual cells in an artificial extracellular
environment, Polacheck and Kamm's system allows them to look at the way cells
interact with tissue that mimics natural breast tissue.
"There isn't a single drug currently on the market that addresses how ...
Sol-gel coatings by flow process of Polyrise